Swansea started with seven players aged 21 or below against Wrexham in midweek and, despite suffering a 1-0 defeat, seems likely to pick another youthful line-up for the Manor Ground clash.
As he plans for next season's Third Division campaign, Hollins is looking to run the rule over his entire squad before the summer break.
"We are trying to give people who would not normally get opportunities a chance," he said.
"It could well be another young side like the one we played against Wrexham.
"The way I look at it, if you give a young player 90 minutes in this division and he copes, he will certainly be able to cope in Division Three next season."
Hollins added:
"We are trying to get a blend of people together for next year and we are looking at every player and every position."
Despite his experimental selections, Hollins is still searching for victories to restore some pride at the end of a sorry season.
"I go out to win every game and we could do with something to get us out of the rut we're in," he said.
"To say bringing the youngsters in reduces our chances of getting a victory would be unfair on them.
"I thought they did very well against Wrexham and we were unlucky not to get a result. We hit the bar twice and the keeper made some good saves.
"It would be nice to get one over on Oxford now because they could well be one of our competitors in Division Three."
Having failed to score in the Welsh derby, Swansea could be boosted by the return of strikers Giovanni Savarese and Steve Watkin.
Savarese is back after making a substitute appearance for Venezuela in their World Cup qualifying clash with Colombia while Watkin has made a good recovery from an ankle problem.
But the treatment room at the Vetch remains a very busy place. Jason Smith, Kris O'Leary, Michael Keegan, Ryan Casey, Steve Jones and Richie Appleby are all out.