David Silva has suffered ligament damage and will miss this weekends Derby, CSKA Moscow in the Champions League and the Premiership clash with QPR, reports The Mirror.
Tests have revealed that Silva, who limped out of Wednesday night's Capital One Cup defeat against Newcastle, will be out of action for three weeks.
Silva was forced off with a knee injury less than ten minutes into the tie as a result of a tackle from by Ryan Taylor.
Silva will also miss Spain's upcoming two fixtures: a Euro 2016 qualifier against Belarus and a friendly against world champions Germany.