If ever Saints need to break that Goodison Park League hoodoo that stretches back to the 1990's, they go there with new confidence after two straight wins in cup competitions., can they turn the Goodison Park atmosphere toxic.
Southampton go to an Everton team in worse form than themselves and with the Toffee's fans now in revolutionary mood and protest planned for both before and after the game, Saints task is clear, get off to a good start, get the crowd on the home teams back and take the 3 points.
Simple, but then again this is Saints.
Nathan Jones has turned a corner this week, he now has to build on that.
Hopefully he will keep things simple, the formation played against Manchester City was one that the players felt comfortable with and they will go into the game with confidence.
Jones problem will be a nice one to have, who plays where and who drops in and out of the side.
Does he keep faith with the starting line up against Manchester City or does he bring back those who were on the bench.
The goalkeeper and three centre backs looked comfortable and in Caleta-Car we seem to have found an organiser at the back and someone who can play the ball.
In the centre of midfield, hopefully Romeo Lavia will be fit to play and we could do worse than keep him paired with Ibrahima Diallo, leaving James Ward Prowse to get forward more.
Kyle Walker Peters has adapted well to the wing back position, but who fills the other role, Moussa Djenepo had a great game capped with a superb ball, does Jones keep faith with him or does he give a League debut to new signing Mislav Orsic.
The Croatian only had 10 minutes or so including injury time against City and had little time to show what he can do, but ultimately he has the experience we need, this decision will be a tough call.
Up front is another toughie, Che Adams was rested against City and in his absence Sekou Mara scored his first goal and Adam Armstrong also had a strong game where he built on his goal at Palace in the FA Cup, Jones has to perm 2 from 3 up front.
All in all though the squad has an extra two men since December and is stronger for it, the players who came on as sub on Wednesday including Moi Elyounoussi & Romain Perraud, plus those getting on such as Sam Edozie, Joe Aribo and indeed those not involved such as Ashley Maitland Niles and new signing Carlos "Charly" Alcaraz will also be hoping to play some part in the game.
So things are looking up for Saints both in terms of the players now available but in the spirit and confidence that has suddenly infused into the squad.
On the other hand Everton must suddenly be a little worried, their players can't be looking forward to playing in front of a crowd that is ready to protest, Saints job is to make sure they have something to get on their teams back for.
An early goal or two would do the trick, Goodison Park in the last 50 years has often been a graveyard for us, we rarely have won there and aside from two games I think, we havent won there in the League since 1974 when we won 3-0 on the final day of the season but it wasn't enough to keep us up.
So what better time to break this hoodoo and in doing so giving us a great chance to pull ourselves up the League table.
A draw would not be a disaster, but defeat is unthinkable and would make avoiding relegation very tough.
Fingers crossed then on Saturday, but we go there in a lot better condition than we were a week ago and that is something I didn't think I would be writing as we headed for South London last weekend or indeed around 30 mins into the Palace game.
We took a big step against City but they are only small steps in the bigger picture, we need to make sure it is another big step on Saturday and make sure that it is the Everton fans singing "Frank Lampard your football is sh*t"
For those going to the game, our Rough Guide To Everton has all the info you need, read it using the link below.
https://www.fansnetwork.co.uk/football/southampton/news/59316/a-rough-guide-to-e