They are not very "Appy Ammers" in the East End at the moment after a bad start to the season and now it has got worse with more injury blows.
West Ham are likely to be without a recognised left back when they take on Saints on Sunday, there first choice Aaron Cresswell is out with a long term injury and now his replacement Arthur Masuaku a £6 million signing from Olympiacos is out for six weeks with a knee ligament injury.
That means that they will have to make contingency plans on the left perhaps switching one of their right backs, either Alvaro Arbeloa or Sam Byram or playing either a youth player or someone completely out of position.
This is a problem with West Ham's defence leaking goals left right and centre having conceded four per game in their last two outings and three in the game before that, so this news is not great for Slaven Bilic as he looks to solve his problems at the back.
Add to the two left back injuries and Saints fans will also be glad to hear that Andy Carroll, so often a thorn in our side will also be missing as will Summer signing Andre Ayew and fellow forward Diafra Sakho.
However central defender Winston Reid is set to return.
Saints go to North London looking for their first win of the season on the road and indeed their first point, from this viewpoint it is a game that looks there for the taking, although this is not always a good sign for Saints supporters from experience.