The West Ham fixture will provide stern test of the squad's ability to cope with reduced numbers, as Saints go through a busy period wracked by injuries with the odd suspension thrown in for good measure.
The visit of West Ham to St Mary's will provide a stern test of Saints' ability to cope with the absence of influential personnel.
While the stalemate against Fulham at Craven Cottage on Boxing Day was disappointing, it was certainly a game Ralph Hasenhuttl's men could and should have claimed victory from.
With Che Adams unable to convert the point blank rebound from James Ward-Prowse's sublime free-kick, two excellent finishes from Shane Long and Theo Walcott chalked off by VAR and a clear handball in the penalty area not given, the chances were there.
In saying that, Saints were far from their best in the first half and, despite the assured performance from Ibrahima Diallo in the centre of midfield, this perhaps again laid bare the frailty of the first team squad.
It is in no doubt Jannik Vestergaard, Oriol Romeu and Danny Ings have all been central to the team's impressive campaign to-date and not having them regardless of the size and quality of the squad would be detrimental.
Nathan Redmond is also a key player both as a first team player and squad member and his absence always takes another layer of threat away.
In a way for me, the fact three points were within reach against a much-improved Fulham outfit despite being without these players provided a shred of comfort.
The visit of the Hammers will provide a different level of test though and, even with the return of Romeu, Saints will be without Vestergaard and are likely to be missing Ings and Redmond.
Against a very capable and threatening West Ham side which sit a place below Saints in the table and will be boosted by the potential return of former Saint Michail Antonio, the ability of Hasenhuttl's men to cope will be put to the test.
Much will come down to the Austrian's selection and tactics as he will expect any team he fields to perform to higher standards than demonstrated for periods against Fulham.
Many would have been looking for six points from these two fixtures given the progress made so far, so anything less than the four now possible will be a blow.
If Saints stutter against the Hammers then it will further highlight the need to invest in the transfer window to ensure there is sufficient quality to maintain consistency in the face of a depleted first eleven for the remainder of the season.
There is only so far the manager's style of play can succeed without the strength in quality needed to excel in the Premier League. If he is able to demonstrate that success can still be achieved against tough opponents it will go a long way to reassuring everyone the squad has just enough within it to continue progressing for now.
However, longer-term investment in additional fire power and central defensive cover will definitely be needed to avoid having weaknesses exposed when influential figures are unavailable.
Failure to claim victory will mean no win in four for Saints heading into a visit from the champions and trip to Leicester City, so there will be no let-up in the challenges ahead.
My hope is the FA Cup tie against Shrewsbury sandwiched between these two fixtures will be a more relaxed opportunity to involve some fringe players rather than a need to end a winless run stretching to five games.