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I don't think it is so obvious on men either - maybe it's that ladies have more of a fat layer under the skin that it shrivels away and so looks worse but I don't know the mechanics of how it works so that's only a guess.
Wouldn't touch them. There is a young girl who comes in to where I work who was pretty and she's used one or other of them and now has that characteristic tell-tale gaunt face that honestly makes her looks older than someone of my age. That's just one of the immediately obvious side effects but there are other serious ones that may or may not affect a person - and not judging anyone as I can see why it's seen as an attractive option but to me it's like playing Russian roulette with your health.
When I was originally on here a few years back I was checking so often my google profile thought I was a middle aged man interested in attic spaces (I am neither of those things).
I think I sailed through it without noticing - but then the men around me may have thought differently . My mum was an angry woman - usually with my dad if he was breathing - so I vowed never to be like that and move on if someone was annoying me that much.