| So ,how we gonna do this season 12:39 - Jul 13 with 5807 views | onehunglow |
Worth a discussion or too early what with this world cup ,which will soon be over and England will get back to reality after losing the final
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| So ,how we gonna do this season on 22:32 - Jul 13 with 1300 views | PawelAbbott |
| So ,how we gonna do this season on 13:38 - Jul 13 by GixerJack |
As already mentioned, a lot depends the squad we start the season with. I’m just hoping for a few early wins to get us going and build a bit of confidence and momentum early on… a bit of a run in the league cup would also be a bonus. |
Does it really depend on the squad? We aren't going to sign a bunch of Premier League players.
We will sign some mediocre Championship players.
We will continue to perform averagely over the course of the season.
At no point will we seriously threaten either end of the table.
We will end up in mid-table. The season will be as monotonous as the preome.
At no point will our promotion be televised. | | | |
| So ,how we gonna do this season on 03:25 - Jul 14 with 1200 views | ncswan |
| So ,how we gonna do this season on 17:04 - Jul 13 by nicky |
I have a blood cancer (relapsed 3.5 years ago).
Been told I’m terminally ill so to attempt to prolong matters I’m avoiding most contact with the outside world as I have no immune system. Sometimes I yearn for the bad old days of 2500 at The Vetch and my own barrier on the NB! |
You've probably know all about the below info but in case you and your medical team haven't seen. From Google's Gemini; the 1st one, CAR T-Cell Therapy, looks promising. Prayers are with you!:
Pharmaceutical and medical advancements in blood cancers (leukemia, lymphoma, and myeloma) have shifted the standard of care from broad-spectrum chemotherapy to highly personalized immunotherapies and targeted treatments. These innovations yield longer remissions and significantly improved survival rates.Key advances center on several transformative technologies:CAR T-Cell Therapy: Doctors remove a patient's T-cells, genetically reprogram them in a lab to target specific cancer proteins, and reinfuse them to hunt down the disease. Once largely a last resort, these therapies are now frequently approved as early as the first relapse, achieving durable, years-long remissions.Bispecific T-Cell Engagers (TCEs): These engineered proteins work by attaching to a patient's T-cell on one arm and a cancer cell on the other, effectively forcing the immune system to recognize and destroy the tumor. Drugs like teclistamab and talquetamab are transforming care for relapsed/refractory multiple myeloma.Targeted Protein Degraders: Novel drugs (like CELMoDs) act as "molecular escorts" that target and trigger the destruction of the specific proteins that drive cancer growth.Next-Generation Inhibitors: For chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML), therapies such as non-covalent BTK inhibitors (e.g., pirtobrutinib) and menin inhibitors are outperforming older treatments while causing fewer side effects.Antibody-Drug Conjugates (ADCs): These treatments combine the precision of an antibody with a highly potent cellular toxin, delivering chemotherapy directly into the cancer cells while sparing healthy tissue.Resources for exploring these options in-depth include:Leukemia & Lymphoma Society: Find patient support and clinical trial matching via Blood Cancer United.Multiple Myeloma Treatment: Read about quadruplet therapies and emerging drugs at the International Myeloma Foundation.Oncology Research: Review the latest clinical data from the Dana-Farber Cancer Institute.If you or a loved one are looking into treatment options, could you share which specific type of blood cancer is being evaluated (e.g., leukemia, lymphoma, or myeloma)? This will help narrow down the most relevant recent clinical breakthroughs.13 sitesAdvances and challenges in blood cancer drug discoveryFeb 26, 2026 — Jeremy Skillington, CEO, Poolbeg Pharma: Blood cancer drug development is an incredibly exciting place right now. There have been ...Drug Discovery World (DDW)Medical Advances in Leukemia ResearchJun 25, 2019 — Targeted therapies. Targeted therapies recently approved to treat AML with certain gene changes include Enasidenib (Idhifa), Oluta...VCU Massey Comprehensive Cancer CenterHaematology Cancer | AstraZenecaThis includes pioneering methods to improve the autologous manufacturing process, to deliver 'younger' and potentially more active...AstraZenecaShow all This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more | | | |
| So ,how we gonna do this season on 03:41 - Jul 14 with 1196 views | ncswan |
| So ,how we gonna do this season on 21:10 - Jul 13 by nicky |
I have multiple myeloma Rich. Diagnosed in 2014. Stem cell transplant the following year then nearly 8 in remission before I relapsed in early 2023.
Chemo not an option for me due to other issues so I’ve been told there’s nothing else that can be done and am therefore terminal.
If you want to PM for a chat then feel welcome :-) |
Hey Nicky,
I hope you don't mind but I googled further with your response here. Gemini responded with the following:
Our friend has multiple myeloma. Diagnosed in 2014. Stem cell transplant the following year then nearly 8 yrs in remission before relapsing in early 2023.
Chemo not an option due to other issues so he's been told there’s nothing else that can be done and is therefore terminal.
I am so sorry to hear your friend is facing this. It is incredibly heavy news to receive, but the information your friend was given is outdated, as multiple myeloma care has completely changed since 2023.Even if traditional chemotherapy is no longer an option due to toxicities or other health conditions, a wave of newly approved, highly targeted immunotherapies are specifically designed for patients who have relapsed multiple times. These treatments do not rely on traditional chemotherapy.
Advanced Myeloma Treatments Approved Post-2023 - If your friend has not yet seen a specialized myeloma oncologist at a major academic research hospital, getting a second opinion immediately is critical. They have access to these recently approved therapies:Bispecific T-Cell Engagers (BiTEs): These are off-the-shelf, non-chemotherapy immunotherapies given as simple injections. They act as bridges, grabbing the patient's own immune T-cells and forcing them to destroy the myeloma cells. Drugs like teclistamab (Tecvayli) and elranatamab (Elrexfio) are specifically FDA-approved for patients who have relapsed after multiple previous lines of therapy.CAR T-Cell Therapies: These therapies involve genetically modifying a patient’s own immune cells to target myeloma proteins (like BCMA). Therapies like ciltacabtagene autoleucel (Carvykt) and idecabtagene vicleucel (Abecma) are now being used much earlier in relapse cases because they can induce deep, rapid remissions even when other drugs fail.Novel Target Classes: For patients whose cancer has grown resistant to common targets, new drugs targeting a different protein called GPRC5D—such as the bispecific antibody talquetamab (Talvey)—provide an entirely new avenue of attack completely distinct from standard treatments.Next Steps for Your FriendBecause general oncologists may not be fully integrated into the rapid pace of myeloma clinical trials and recent FDA approvals, taking these active steps can open up new possibilities:Consult a Myeloma Specialist: Use the International Myeloma Foundation Specialist Directory to find an expert. A specialist at a National Cancer Institute (NCI)-designated cancer center will know exactly how to safely administer immunotherapies to patients who cannot tolerate standard chemo.Contact a Patient Navigator: The Leukemia & Lymphoma Society (LLS) Information Specialists offer free, one-on-one support to help families navigate difficult diagnoses, understand novel immunotherapies, and coordinate fast second opinions.Explore Specialized Clinical Trials: Many cutting-edge therapies (like CELMoDs or next-generation bispecifics) are available through clinical trials specifically designed for relapsed patients with complex medical backgrounds.Would you like help finding the closest NCI-designated cancer center or multiple myeloma specialist in your friend's general area? If you can share their approximate city or state, I can locate specialized centers for a second opinion.This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more13 sitesMyeloma Relapse Rates and 9 Treatment Options for RelapsesJan 2, 2025 — Many people with multiple myeloma eventually become resistant to IMiDs, proteasome inhibitors, and monoclonal antibodies, so they ...MyMyelomaTeamTreating Multiple MyelomaWe are proud to be able to offer our patients the most recent advances and promising treatments for multiple myeloma through these...Fox Chase Cancer CenterMyeloma TreatmentBiTES monoclonal antibody is the latest class of therapy where cells are genetically modified and constructed in a laboratory. Unl...Vancouver Myeloma SupportShow all | | | |
| So ,how we gonna do this season on 09:10 - Jul 14 with 1102 views | onehunglow |
| So ,how we gonna do this season on 21:10 - Jul 13 by nicky |
I have multiple myeloma Rich. Diagnosed in 2014. Stem cell transplant the following year then nearly 8 in remission before I relapsed in early 2023.
Chemo not an option for me due to other issues so I’ve been told there’s nothing else that can be done and am therefore terminal.
If you want to PM for a chat then feel welcome :-) |
Thanks Nicky
Keep in touch | |
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| So ,how we gonna do this season on 09:11 - Jul 14 with 1102 views | grabsplatter |
Best wishes to both of you fighting this horrible disease.
To anyone else out there who's fit & healthy I'd appeal to you to volunteer to give regular blood donations & put yourself on the bone marrow donation list as well if you can. |  | | |
| So ,how we gonna do this season on 09:20 - Jul 14 with 1097 views | onehunglow |
| So ,how we gonna do this season on 09:11 - Jul 14 by grabsplatter |
Best wishes to both of you fighting this horrible disease.
To anyone else out there who's fit & healthy I'd appeal to you to volunteer to give regular blood donations & put yourself on the bone marrow donation list as well if you can. |
Sweet | |
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| So ,how we gonna do this season on 13:31 - Jul 14 with 998 views | nicky |
| So ,how we gonna do this season on 03:41 - Jul 14 by ncswan |
Hey Nicky,
I hope you don't mind but I googled further with your response here. Gemini responded with the following:
Our friend has multiple myeloma. Diagnosed in 2014. Stem cell transplant the following year then nearly 8 yrs in remission before relapsing in early 2023.
Chemo not an option due to other issues so he's been told there’s nothing else that can be done and is therefore terminal.
I am so sorry to hear your friend is facing this. It is incredibly heavy news to receive, but the information your friend was given is outdated, as multiple myeloma care has completely changed since 2023.Even if traditional chemotherapy is no longer an option due to toxicities or other health conditions, a wave of newly approved, highly targeted immunotherapies are specifically designed for patients who have relapsed multiple times. These treatments do not rely on traditional chemotherapy.
Advanced Myeloma Treatments Approved Post-2023 - If your friend has not yet seen a specialized myeloma oncologist at a major academic research hospital, getting a second opinion immediately is critical. They have access to these recently approved therapies:Bispecific T-Cell Engagers (BiTEs): These are off-the-shelf, non-chemotherapy immunotherapies given as simple injections. They act as bridges, grabbing the patient's own immune T-cells and forcing them to destroy the myeloma cells. Drugs like teclistamab (Tecvayli) and elranatamab (Elrexfio) are specifically FDA-approved for patients who have relapsed after multiple previous lines of therapy.CAR T-Cell Therapies: These therapies involve genetically modifying a patient’s own immune cells to target myeloma proteins (like BCMA). Therapies like ciltacabtagene autoleucel (Carvykt) and idecabtagene vicleucel (Abecma) are now being used much earlier in relapse cases because they can induce deep, rapid remissions even when other drugs fail.Novel Target Classes: For patients whose cancer has grown resistant to common targets, new drugs targeting a different protein called GPRC5D—such as the bispecific antibody talquetamab (Talvey)—provide an entirely new avenue of attack completely distinct from standard treatments.Next Steps for Your FriendBecause general oncologists may not be fully integrated into the rapid pace of myeloma clinical trials and recent FDA approvals, taking these active steps can open up new possibilities:Consult a Myeloma Specialist: Use the International Myeloma Foundation Specialist Directory to find an expert. A specialist at a National Cancer Institute (NCI)-designated cancer center will know exactly how to safely administer immunotherapies to patients who cannot tolerate standard chemo.Contact a Patient Navigator: The Leukemia & Lymphoma Society (LLS) Information Specialists offer free, one-on-one support to help families navigate difficult diagnoses, understand novel immunotherapies, and coordinate fast second opinions.Explore Specialized Clinical Trials: Many cutting-edge therapies (like CELMoDs or next-generation bispecifics) are available through clinical trials specifically designed for relapsed patients with complex medical backgrounds.Would you like help finding the closest NCI-designated cancer center or multiple myeloma specialist in your friend's general area? If you can share their approximate city or state, I can locate specialized centers for a second opinion.This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more13 sitesMyeloma Relapse Rates and 9 Treatment Options for RelapsesJan 2, 2025 — Many people with multiple myeloma eventually become resistant to IMiDs, proteasome inhibitors, and monoclonal antibodies, so they ...MyMyelomaTeamTreating Multiple MyelomaWe are proud to be able to offer our patients the most recent advances and promising treatments for multiple myeloma through these...Fox Chase Cancer CenterMyeloma TreatmentBiTES monoclonal antibody is the latest class of therapy where cells are genetically modified and constructed in a laboratory. Unl...Vancouver Myeloma SupportShow all |
Thank you :-)
I’m mindful of completely derailing this thread but just to say that the haematology team at singleton are excellent and at the cutting edge of treatments.
Unfortunately I have quite a complex medical history (mainly cardiac related along with a history of near fatal blood clots) and therefore not all treatments are suitable for me.
I’ve found looking after myself as best I can l, avoiding infection and staying as healthy as possible are my best options.
Now if only our beloved football team can deliver a season to remember I’ll be extremely happy! |  | | |
| So ,how we gonna do this season on 14:34 - Jul 14 with 958 views | onehunglow |
| So ,how we gonna do this season on 13:31 - Jul 14 by nicky |
Thank you :-)
I’m mindful of completely derailing this thread but just to say that the haematology team at singleton are excellent and at the cutting edge of treatments.
Unfortunately I have quite a complex medical history (mainly cardiac related along with a history of near fatal blood clots) and therefore not all treatments are suitable for me.
I’ve found looking after myself as best I can l, avoiding infection and staying as healthy as possible are my best options.
Now if only our beloved football team can deliver a season to remember I’ll be extremely happy! |
I’m comforted by you living more than ten yrs after diagnosis Nicky
It’s the mental side zim struggling with
Being aggressive by nature might help though
Thanks | |
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| So ,how we gonna do this season on 14:39 - Jul 14 with 951 views | KeithHaynes |
| So ,how we gonna do this season on 13:31 - Jul 14 by nicky |
Thank you :-)
I’m mindful of completely derailing this thread but just to say that the haematology team at singleton are excellent and at the cutting edge of treatments.
Unfortunately I have quite a complex medical history (mainly cardiac related along with a history of near fatal blood clots) and therefore not all treatments are suitable for me.
I’ve found looking after myself as best I can l, avoiding infection and staying as healthy as possible are my best options.
Now if only our beloved football team can deliver a season to remember I’ll be extremely happy! |
Always an ear on this forum or by DM Nicky 👍 |  |
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| So ,how we gonna do this season on 16:51 - Jul 14 with 894 views | FullSentenceSwan |
Guys - sorry to hear you are living with that vile disease. Let's hope the Swans can give you some entertainment. Best wishes to you both and anyone else in a similar situation. [Post edited 16 Jul 18:28]
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| So ,how we gonna do this season on 17:42 - Jul 14 with 860 views | Luther27 |
| So ,how we gonna do this season on 13:31 - Jul 14 by nicky |
Thank you :-)
I’m mindful of completely derailing this thread but just to say that the haematology team at singleton are excellent and at the cutting edge of treatments.
Unfortunately I have quite a complex medical history (mainly cardiac related along with a history of near fatal blood clots) and therefore not all treatments are suitable for me.
I’ve found looking after myself as best I can l, avoiding infection and staying as healthy as possible are my best options.
Now if only our beloved football team can deliver a season to remember I’ll be extremely happy! |
I’m sure they’ll do their best Nicky…however there may be a few moments along the way that makes you wonder why you love football and the Swans so much.
I very much hope you are here the next few seasons to pass judgment on our maddening/wonderful team.
All the very best. | | | |
| So ,how we gonna do this season on 18:08 - Jul 14 with 841 views | onehunglow |
| So ,how we gonna do this season on 17:42 - Jul 14 by Luther27 |
I’m sure they’ll do their best Nicky…however there may be a few moments along the way that makes you wonder why you love football and the Swans so much.
I very much hope you are here the next few seasons to pass judgment on our maddening/wonderful team.
All the very best. |
I will try to ensure he does stay around as I’m not sure I’ve annoyed, irritated , angered or pisssed him off
I will be on your case Nicky Bach  | |
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| So ,how we gonna do this season on 20:52 - Jul 14 with 769 views | GVJack |
Sorry to hear Nicky and OHL. Keep up the fight lads and look after yourselves. | | | |
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