| Vaccine 16:16 - Nov 9 with 7217 views | britferry |
10 million to be given by end of year, it will prevent Covid in 90%... is the end in sight? |  |
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| Vaccine on 22:18 - Nov 19 with 646 views | Nortbankboy |
| Vaccine on 11:40 - Nov 19 by Scotia |
As I understand this one is the game changer for the UK. We'll have enough to vaccinate the entire population with this vaccine alone and it is easy to store and transport.
If this can reach anywhere near the efficacy of Pfizer and Moderna when results are known we can start thinking about an almost normal summer. |
Do you think the Tories will try to make money out this aswell? | | | |
| Vaccine on 22:24 - Nov 19 with 640 views | KeithHaynes |
It’s hard to believe that any govt won’t turn it in to a money maker. |  |
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| Vaccine on 22:28 - Nov 19 with 634 views | Nortbankboy |
| Vaccine on 22:24 - Nov 19 by KeithHaynes |
It’s hard to believe that any govt won’t turn it in to a money maker. |
Especially this government,can't wait to see who they hand the contracts on to! | | | |
| Vaccine on 22:36 - Nov 19 with 624 views | Professor |
| Vaccine on 09:09 - Nov 15 by A_Fans_Dad |
Well what do you know?
Yet another non anti-viral drug like HCQ stops COVID patients from dying.
This time it is the Arthritis drug called baricitinib, and marketed under the brand name Olumiant.
It reduces deaths in the elderly by 71% by reducing the spread of the virus, especially to the lungs.
Expect the prof to be along any minute to call these doctors lots of bad names as it can't possibly work, because he says so. |
Inhibits the JAK-STAT pathway which is key in pro-inflammatory cytokine signalling. Same idea as steroids, but working in a different way. Will do nothing to stop viral spread or replication (May in fact do the reverse) but like dexamethasone should help those with severe disease. Still not an answer but another Useful therapeutic tool. Although this info was around in August | | | |
| Vaccine on 22:49 - Nov 19 with 614 views | Nortbankboy |
| Vaccine on 22:36 - Nov 19 by Professor |
Inhibits the JAK-STAT pathway which is key in pro-inflammatory cytokine signalling. Same idea as steroids, but working in a different way. Will do nothing to stop viral spread or replication (May in fact do the reverse) but like dexamethasone should help those with severe disease. Still not an answer but another Useful therapeutic tool. Although this info was around in August |
There's enough roiders in Swansea as it is | | | |
| Vaccine on 22:54 - Nov 19 with 605 views | Professor |
| Vaccine on 22:49 - Nov 19 by Nortbankboy |
There's enough roiders in Swansea as it is |
Corticosteroids rather than anabolic. Give you a flushed round face not muscles! Just had a puff on mine. | | | |
| Vaccine on 23:03 - Nov 19 with 601 views | Professor |
| Vaccine on 11:40 - Nov 19 by Scotia |
As I understand this one is the game changer for the UK. We'll have enough to vaccinate the entire population with this vaccine alone and it is easy to store and transport.
If this can reach anywhere near the efficacy of Pfizer and Moderna when results are known we can start thinking about an almost normal summer. |
We will see. I’m a bit more cautious than you on this but pleasantly surprised by the reported efficacy of the RNA vaccines. Speaking to a colleague earlier this week there are some concerns over mutational change in the spike protein, which may need vaccines to be updated regularly,
But this is much less than in flu. The big question is field efficacy where the Oxford Vaccine should have some advantage in its robustness.
Not been widely reported but the Oxford group made some big advances in understanding of protection against Typhoid this week. This is also good news but buried in the pandemic. | | | |
| Vaccine on 07:08 - Nov 20 with 543 views | Scotia |
| Vaccine on 23:03 - Nov 19 by Professor |
We will see. I’m a bit more cautious than you on this but pleasantly surprised by the reported efficacy of the RNA vaccines. Speaking to a colleague earlier this week there are some concerns over mutational change in the spike protein, which may need vaccines to be updated regularly,
But this is much less than in flu. The big question is field efficacy where the Oxford Vaccine should have some advantage in its robustness.
Not been widely reported but the Oxford group made some big advances in understanding of protection against Typhoid this week. This is also good news but buried in the pandemic. |
Cheers Prof.
Let's hope the vaccines can be adapted pretty quickly and any changes don't stop the current batch of vaccines working when they are rolled out.
Good news about Typhoid I'm hoping that one of the advantages of this pandemic will be developments in other treatments. | | | |
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| Vaccine on 08:13 - Nov 20 with 533 views | felixstowe_jack |
More good news is the WHO is also going to roll out vaccination world wide for the virus then causes most cervical cancers. | |
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| Vaccine on 09:16 - Nov 20 with 522 views | Professor |
| Vaccine on 08:13 - Nov 20 by felixstowe_jack |
More good news is the WHO is also going to roll out vaccination world wide for the virus then causes most cervical cancers. |
HPV- been really successful in UK. Good to see this . | | | |
| Vaccine on 09:19 - Nov 20 with 521 views | Professor |
| Vaccine on 07:08 - Nov 20 by Scotia |
Cheers Prof.
Let's hope the vaccines can be adapted pretty quickly and any changes don't stop the current batch of vaccines working when they are rolled out.
Good news about Typhoid I'm hoping that one of the advantages of this pandemic will be developments in other treatments. |
It should be. Coronaviruses are pretty simple antigenically with the Spike Protein the only realistic target. The RNA vaccines should be simple enough to change the sequence and the vector vaccines just add the new variant code into the recombinant adenovirus. The basic principle won't change, just a slight coding change. It's a lot less variable than flu and does not have the mass of variants to start with. | | | |
| Vaccine on 10:26 - Nov 20 with 505 views | onehunglow |
How do the anti vaxes feel today?
Wrong? | |
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| Vaccine on 10:43 - Nov 20 with 500 views | controversial_jack |
| Vaccine on 10:26 - Nov 20 by onehunglow |
How do the anti vaxes feel today?
Wrong? |
The Oxford one is already proving to be ineffective after dozens of volunteers have become infected. The Russian one the same. | | | |
| Vaccine on 10:55 - Nov 20 with 495 views | Scotia |
| Vaccine on 10:43 - Nov 20 by controversial_jack |
The Oxford one is already proving to be ineffective after dozens of volunteers have become infected. The Russian one the same. |
The trial hasn't been unblinded yet so nobody knows that. Even if dozens have been infected it doesn't mean it is ineffective. It needs to demonstrate at least 50% fewer infections than placebo really.
Obviously Russian data needs to be taken with a pinch of salt, but apparently medics have been infected after one dose of a two dose vaccine. [Post edited 20 Nov 2020 10:57]
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| Vaccine on 11:13 - Nov 20 with 486 views | controversial_jack |
| Vaccine on 10:55 - Nov 20 by Scotia |
The trial hasn't been unblinded yet so nobody knows that. Even if dozens have been infected it doesn't mean it is ineffective. It needs to demonstrate at least 50% fewer infections than placebo really.
Obviously Russian data needs to be taken with a pinch of salt, but apparently medics have been infected after one dose of a two dose vaccine. [Post edited 20 Nov 2020 10:57]
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They do know, they have said, Pfizer the same, they have had dozens of infection. It has to be 100% to demonstrate that it works | | | |
| Vaccine on 11:34 - Nov 20 with 482 views | Scotia |
| Vaccine on 11:13 - Nov 20 by controversial_jack |
They do know, they have said, Pfizer the same, they have had dozens of infection. It has to be 100% to demonstrate that it works |
It doesn't have to be 100% the general rule is 50% to be authorised to be used, the flu vaccine is frequently nowhere near even 50% effective.
I'm pretty certain that no vaccine in the world has ever been 100% effective.
They haven't unblinded the results yet, they haven't had enough infections across the phase 3 trial group yet. I've been part of a trial and I have no idea what vaccine I had.
Dr Varasamy (I think) from Oxford uni said as much on BBC breakfast yesterday. | | | |
| Vaccine on 11:47 - Nov 20 with 477 views | Professor |
| Vaccine on 11:34 - Nov 20 by Scotia |
It doesn't have to be 100% the general rule is 50% to be authorised to be used, the flu vaccine is frequently nowhere near even 50% effective.
I'm pretty certain that no vaccine in the world has ever been 100% effective.
They haven't unblinded the results yet, they haven't had enough infections across the phase 3 trial group yet. I've been part of a trial and I have no idea what vaccine I had.
Dr Varasamy (I think) from Oxford uni said as much on BBC breakfast yesterday. |
No vaccine is 100% effective. In fact levels found for the Pfizer and ModeRna vaccines are very high in terms of efficacy. I am pretty sure that they will not know the unblinded results yet or Astra Zeneca would announce something. I know a few people in the Oxford Group (I was a PhD examiner with Andrew Pollard a couple of years ago) and they are pretty trustworthy in my opinion.
Anything over 80% would be a big success. The proof for all the candidates is in the field though. | | | |
| Vaccine on 11:53 - Nov 20 with 475 views | onehunglow |
Well,it IS something and right now,we need some hope.
80% 50% is better than 0% | |
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| Vaccine on 12:14 - Nov 20 with 467 views | felixstowe_jack |
| Vaccine on 10:43 - Nov 20 by controversial_jack |
The Oxford one is already proving to be ineffective after dozens of volunteers have become infected. The Russian one the same. |
Has the oxford virus even been trialled in Russia? Is this the same oxford virus that Putin claimed turned people into monkey? | |
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| Vaccine on 12:23 - Nov 20 with 460 views | A_Fans_Dad |
| Vaccine on 22:54 - Nov 19 by Professor |
Corticosteroids rather than anabolic. Give you a flushed round face not muscles! Just had a puff on mine. |
Plus a buffalo hump and weak muscles, which my wife developed. | | | |
| Vaccine on 12:27 - Nov 20 with 459 views | A_Fans_Dad |
| Vaccine on 11:53 - Nov 20 by onehunglow |
Well,it IS something and right now,we need some hope.
80% 50% is better than 0% |
But 50% is not as good as a medicine that saves 70% of those that get it.
It won't be much use if the 50% are all under 50 years of age. | | | |
| Vaccine on 12:41 - Nov 20 with 455 views | Professor |
| Vaccine on 12:27 - Nov 20 by A_Fans_Dad |
But 50% is not as good as a medicine that saves 70% of those that get it.
It won't be much use if the 50% are all under 50 years of age. |
Thats's a daft statement. It's not binary. Life or death. A colleague of mine in her 40s, very fit and healthy has been laid low for a second time. Prevention is better than cure. The treatments are helping, yes, but this is in the most severe cases. A 50% vaccine is more beneficial for a population than a good ICU therapeutic. | | | |
| Vaccine on 13:02 - Nov 20 with 445 views | onehunglow |
| Vaccine on 12:27 - Nov 20 by A_Fans_Dad |
But 50% is not as good as a medicine that saves 70% of those that get it.
It won't be much use if the 50% are all under 50 years of age. |
So ,we just wait until a vaccine that is guaranteed 100% to come along? | |
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| Vaccine on 13:25 - Nov 20 with 441 views | Professor |
| Vaccine on 12:14 - Nov 20 by felixstowe_jack |
Has the oxford virus even been trialled in Russia? Is this the same oxford virus that Putin claimed turned people into monkey? |
No-Brazil, South Africa and the UK- Southampton and Liverpool have been main trial centres.
The attenuated (disabled) virus used as a vector is an adenovirus from Chimps which should not really replicate well in humans. Viral and bacterial vectors carry genes of the target pathogen which produce the protein which is then targeted by the immune system. The advantage of this way is you can 'over express' your target protein, so there is far more around than in an infection and hence a better response. Vectors are usually used that target where you want a response-so adenoviruses into the respiratory tract for example. There are quite a few in use, particularly in companion animal vaccines (dogs, cats, horses). | | | |
| Vaccine on 13:31 - Nov 20 with 439 views | A_Fans_Dad |
| Vaccine on 13:02 - Nov 20 by onehunglow |
So ,we just wait until a vaccine that is guaranteed 100% to come along? |
No, we use the bloody medicines that have been shown to save lives, instead of all the emphasis being on the untried Vacines. | | | |
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