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Corona Virus 22:39 - Mar 7 with 220747 viewsSgorioFruit

Sorry for new thread,
But how bad do you lot reckon it’s going to get here in the UK?
I just been watching the news. Looking nasty in Italy.

My methods are not favoured by some but by god i speak the truth.
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Corona Virus on 23:25 - Apr 15 with 1261 viewschad

Corona Virus on 21:00 - Apr 15 by Dr_Winston

By making it to that age it would suggest a robust constitution and genetic makeup in the first place. Luck of the parental lottery for the most part. Depends how much of the virus she copped in the first place too.


I might have called her redoubtable, she of course calls herself lucky which is very true.

I was going to mention DNA but obviously goes a lot further than that, these things I am sure can turn on the most simple of things but as you say so many variables.

There is still so much unknown about the Spanish flu pandemic and scientists still argue over all the ways flu spreads. Will we ever know everything, don’t they say there is no such thing as scientific proof, only evidence that we can add to our imperfect understanding.
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Corona Virus on 23:48 - Apr 15 with 1236 viewsJack123

Corona Virus on 22:30 - Apr 15 by lifelong

Some are saying today that lockdown restrictions could ease within the next few weeks, but they shouldn’t be relaxed completely until a vaccine is available, that could be many months before we get back to normality....very sobering thought.
[Post edited 15 Apr 22:34]


Depending on how the figures look within the next week, I'm thinking it should be a harsher lockdown, not relaxing it.

Considering we are all on pretty high alert, an example today in Tesco, as i was trying to find a big packet of washing powder, spent all of 20 seconds frantically searching for it, wasn't good enough for this *(&k next to me, nearly touched me trying to get what they want..
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Corona Virus on 00:09 - Apr 16 with 1202 viewschad

Corona Virus on 20:14 - Apr 15 by londonlisa2001

The simplistic answer is that it’s the luck of the draw.

The answer that may emerge down the line could be that there is a genetic influence determining how some are getting it far more severely than others. Added to there being a difference in outcomes depending on the viral load. And potentially that certain illnesses and/or medications and vaccines received in the past may be having an effect. The BCG being one theory.

Everyone is struck by the disproportionate number of severe and fatal outcomes in people of an ethnic minority background in the UK. A Jewish background as well. It may be due to cultural differences (multi generational living), it may be due to an over representation of those communities in the health service and amongst carers, or it may point to some substance in theories of genetic dispositions to different outcomes.


Agree with all of that

Sure the ethnic differences are a combination of all those things. Also specifically mentioned darker skin, obviously adapted to stronger sun protection in hotter climates, leading to a potential vitamin D shortage in our lesser sun. Doctor even recommended supplements.
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Corona Virus on 07:26 - Apr 16 with 1089 viewsScotia

Corona Virus on 22:52 - Apr 15 by Professor

Sarah, Adrian Hill and Helen McShane at the Jenner Institute are all very good. They usually get good results in U.K. trials but generally their vaccines have been less effective in field trials ( mainly in Africa for malaria and TB). Let’s hope this one works


It was definitely the Jenner institute and a female.

I just hope something works and as soon as possible.
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Corona Virus on 10:20 - Apr 16 with 1007 viewsProfessor

Corona Virus on 00:09 - Apr 16 by chad

Agree with all of that

Sure the ethnic differences are a combination of all those things. Also specifically mentioned darker skin, obviously adapted to stronger sun protection in hotter climates, leading to a potential vitamin D shortage in our lesser sun. Doctor even recommended supplements.


There are multiple genetic factors and epigenetic factors at play. The most obvious one is distribution of the differing ACE2 receptor types that the virus targets for cell entry. Typically this is a weak point of any virus in the need for a specific type of receptor which means that a population or ethnic group that may have a greater or lesser amount of the specific receptor that SARs-CoV2 uses. The specificity also means that viruses rarely species 'jump'.

Secondly there will be a big immunogenetics component based on a molecule called MHC. MHC Class I molecules are on most cells and allow the immune system to recognise if a cell in cancerous or infected. Class II are on specialised cells which present antigen to receptors on host lymphocytes which lead to the generation of antibody responses. We each have 6 different class I and II molecules. The right MHC type is needed to effectively deal with a pathogen-if you have the right one in your armoury you get a better immune response. As each molecule is polymorphic we can deal with many infections (personal survival) but variation in the types in a population lead to at least some of the population being effective against any individual challenge. There will be masses of other variations in the immune system ranging on how effective cells like macrophages are at killing the virus, how well we regulate inflammation and so on.

There are also non-immune factors e.g. sickle cell trait which gives more resistance to malaria, and perhaps even vitamin D (though seems unlikely) but lifestyle factors lead to non-genetic changes or epigenetic changes that can lead to marked differences in resistance-e.g. exposure to pollution, a specific diet components. I am not talking of obesity and other obvious factors, but subtle changes we don't easily see
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Corona Virus on 10:21 - Apr 16 with 1002 viewsNotLoyal

Corona Virus on 10:20 - Apr 16 by Professor

There are multiple genetic factors and epigenetic factors at play. The most obvious one is distribution of the differing ACE2 receptor types that the virus targets for cell entry. Typically this is a weak point of any virus in the need for a specific type of receptor which means that a population or ethnic group that may have a greater or lesser amount of the specific receptor that SARs-CoV2 uses. The specificity also means that viruses rarely species 'jump'.

Secondly there will be a big immunogenetics component based on a molecule called MHC. MHC Class I molecules are on most cells and allow the immune system to recognise if a cell in cancerous or infected. Class II are on specialised cells which present antigen to receptors on host lymphocytes which lead to the generation of antibody responses. We each have 6 different class I and II molecules. The right MHC type is needed to effectively deal with a pathogen-if you have the right one in your armoury you get a better immune response. As each molecule is polymorphic we can deal with many infections (personal survival) but variation in the types in a population lead to at least some of the population being effective against any individual challenge. There will be masses of other variations in the immune system ranging on how effective cells like macrophages are at killing the virus, how well we regulate inflammation and so on.

There are also non-immune factors e.g. sickle cell trait which gives more resistance to malaria, and perhaps even vitamin D (though seems unlikely) but lifestyle factors lead to non-genetic changes or epigenetic changes that can lead to marked differences in resistance-e.g. exposure to pollution, a specific diet components. I am not talking of obesity and other obvious factors, but subtle changes we don't easily see


Not sure if you have heard of him, but have you listened to the theories of Bruce Lipton?

Everyone thinks someone is a cûnt, even those who they don’t thinks are cûnts are cûnts to someone else.
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Corona Virus on 10:32 - Apr 16 with 996 viewsProfessor

Corona Virus on 10:21 - Apr 16 by NotLoyal

Not sure if you have heard of him, but have you listened to the theories of Bruce Lipton?


I have not, but our rush into genomics through sequencing has rather left the idea of epigenetics on the fringe. Whilst our genetics programme us, are our blueprint, it should still be obvious external factors can change things. I recently had a lovely grant application with a guy in Glasgow bounced (rejected) which was based on epigenetic effects of water acidification in livestock (which reduces bacterial numbers like vinegar in pickling) driving the increased virulence in some pathogenic bacteria. Just did not get a high enough score-some very good reviews, others a bit meh!
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Corona Virus on 13:26 - Apr 16 with 919 viewsNotLoyal

Corona Virus on 10:32 - Apr 16 by Professor

I have not, but our rush into genomics through sequencing has rather left the idea of epigenetics on the fringe. Whilst our genetics programme us, are our blueprint, it should still be obvious external factors can change things. I recently had a lovely grant application with a guy in Glasgow bounced (rejected) which was based on epigenetic effects of water acidification in livestock (which reduces bacterial numbers like vinegar in pickling) driving the increased virulence in some pathogenic bacteria. Just did not get a high enough score-some very good reviews, others a bit meh!


It’s worth subscribing to the channel, costs nought.
Have a cup of tea and a listen.

https://londonreal.tv/dr-bruce-lipton-coronavirus-epigenetics-immune-system-most

Everyone thinks someone is a cûnt, even those who they don’t thinks are cûnts are cûnts to someone else.
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Corona Virus on 14:07 - Apr 16 with 864 viewsOldjack

Until there's a cure which is around 18 months away Football is fuked

Prosser the Tosser dwells on Phil's bum hole like a rusty old hemorrhoid ,fact You Greedy Bastards Get Out Of OUR Club!

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Corona Virus on 16:45 - Apr 16 with 771 viewsThrasher6

More than nine in 10 people dying with coronavirus have an underlying health condition, figures from the Office for National Statistics show.

https://www.bbc.co.uk/news/health-52308783

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Corona Virus on 18:09 - Apr 16 with 710 viewssainthelens

Long chat with Mrs SH, question being with the lockdown set to continue for at least another month ( lot likely lot longer), and with the massive effect that will have on people's mental health....is it a matter of time that a breakdown of law n order will be the result? Patience will be running very thin without a sign of normality and a vaccine.
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Corona Virus on 18:20 - Apr 16 with 686 viewsraynor94

Corona Virus on 14:07 - Apr 16 by Oldjack

Until there's a cure which is around 18 months away Football is fuked


Do you really care about football at this time?

You give it out, you take it back it`s all part of the game

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Corona Virus on 18:23 - Apr 16 with 678 viewslifelong

Corona Virus on 18:09 - Apr 16 by sainthelens

Long chat with Mrs SH, question being with the lockdown set to continue for at least another month ( lot likely lot longer), and with the massive effect that will have on people's mental health....is it a matter of time that a breakdown of law n order will be the result? Patience will be running very thin without a sign of normality and a vaccine.


This is a major concern, there is already a lot of desperate people about, with this lockdown dragging on into the summer months this desperation will get a lot worse.
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Corona Virus on 18:31 - Apr 16 with 656 viewsmonmouth

Corona Virus on 14:07 - Apr 16 by Oldjack

Until there's a cure which is around 18 months away Football is fuked


Mate, until something radically changes the world is f*cked. Football can go and stick itself up its ridiculously self important arse.

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Corona Virus on 18:40 - Apr 16 with 644 viewssainthelens

Corona Virus on 18:23 - Apr 16 by lifelong

This is a major concern, there is already a lot of desperate people about, with this lockdown dragging on into the summer months this desperation will get a lot worse.


This is my worry. Until there is actually a vaccine...how can anything possibly return to anything like normality? Coming outa lockdown will just see spike after spike in infections. Is it straightforward as that ?
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Corona Virus on 18:48 - Apr 16 with 629 viewsFlashberryjack

Corona Virus on 18:40 - Apr 16 by sainthelens

This is my worry. Until there is actually a vaccine...how can anything possibly return to anything like normality? Coming outa lockdown will just see spike after spike in infections. Is it straightforward as that ?


I think we will be watching very closely other countries as they relax their lockdown measurers before we make any decision on how and when we edge out of lockdown.

Hello

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Corona Virus on 18:52 - Apr 16 with 623 viewsexiledclaseboy

Corona Virus on 18:20 - Apr 16 by raynor94

Do you really care about football at this time?


Nah I’m more worried about the cricket season.

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Corona Virus on 18:56 - Apr 16 with 613 viewsexiledclaseboy

Corona Virus on 18:40 - Apr 16 by sainthelens

This is my worry. Until there is actually a vaccine...how can anything possibly return to anything like normality? Coming outa lockdown will just see spike after spike in infections. Is it straightforward as that ?


It won’t be a case of “right folks, lockdown’s over let’s all go down the pub and to the footie”. It’ll be phased, possibly by age and definitely by economic sector. What we once knew as “normal” won’t be back this year

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Corona Virus on 19:06 - Apr 16 with 605 viewssainthelens

Corona Virus on 18:56 - Apr 16 by exiledclaseboy

It won’t be a case of “right folks, lockdown’s over let’s all go down the pub and to the footie”. It’ll be phased, possibly by age and definitely by economic sector. What we once knew as “normal” won’t be back this year


If you say by age...how the fck will that work. My local park is full of pensioners, you'll never keep em indoors.
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Corona Virus on 19:08 - Apr 16 with 602 viewsNeath_Jack

Corona Virus on 18:56 - Apr 16 by exiledclaseboy

It won’t be a case of “right folks, lockdown’s over let’s all go down the pub and to the footie”. It’ll be phased, possibly by age and definitely by economic sector. What we once knew as “normal” won’t be back this year


Over 50's kept indoors for the next 6 - 9 months, sounds about right.

I want a mate like Flashberryjacks, who wears a Barnsley jersey with "Swans are my second team" on the back.
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Corona Virus on 19:12 - Apr 16 with 593 viewsexiledclaseboy

Corona Virus on 19:06 - Apr 16 by sainthelens

If you say by age...how the fck will that work. My local park is full of pensioners, you'll never keep em indoors.


Well if there are pensioners out and about now (and my in laws were much the same until recently) no kind of lockdown will stop them. By age I meant kids start going back to school on a staggered basis, people under 30 will be allowed to return to non-essential work etc. We have the advantage of watching other coutures ease their restrictions first so we can see what does and doesn’t work there. We had that advantage at the start of course and took no notice so f*ck knows.

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Corona Virus on 19:18 - Apr 16 with 582 viewssainthelens

Corona Virus on 19:12 - Apr 16 by exiledclaseboy

Well if there are pensioners out and about now (and my in laws were much the same until recently) no kind of lockdown will stop them. By age I meant kids start going back to school on a staggered basis, people under 30 will be allowed to return to non-essential work etc. We have the advantage of watching other coutures ease their restrictions first so we can see what does and doesn’t work there. We had that advantage at the start of course and took no notice so f*ck knows.


Fair points buddy, but policing any potential changes wether be schools/ages etc I'd say be nigh on impossible.
My original point of everyone's mental health deteriorating is a big worry.
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Corona Virus on 19:20 - Apr 16 with 575 viewsexiledclaseboy

Corona Virus on 19:18 - Apr 16 by sainthelens

Fair points buddy, but policing any potential changes wether be schools/ages etc I'd say be nigh on impossible.
My original point of everyone's mental health deteriorating is a big worry.


I agree with you, an extended lockdown will have a big impact on many people’s mental well-being. I have the advantage of being pretty antisocial normally so for now it’s not bothering me too much, if at all.

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Corona Virus on 19:24 - Apr 16 with 566 viewsmonmouth

Snap. My life is much the same, and I don’t have to feel any unease for not having any friends. As long as I can get food and beer and work remotely to get the money to pay for the quantity of beer I need, I can do lockdown until hell freezes over.

Or strictly come dancing is allowed back on.

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Corona Virus on 19:25 - Apr 16 with 1180 viewsexiledclaseboy

Corona Virus on 19:24 - Apr 16 by monmouth

Snap. My life is much the same, and I don’t have to feel any unease for not having any friends. As long as I can get food and beer and work remotely to get the money to pay for the quantity of beer I need, I can do lockdown until hell freezes over.

Or strictly come dancing is allowed back on.


Are you me?

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